Growing scrutiny of prostaglandin-based eyelash serums is prompting more consumers to examine ingredient lists before purchasing products designed to enhance lash length and fullness. Regulators and eye health experts have recently renewed warnings about the potential side effects associated with prostaglandin analogues in cosmetic products, fueling interest in peptide-based and plant-derived alternatives. In response to this shift, Trybello has published a comparative guide examining several popular eyelash serums, including GrandeLASH-MD, The Ordinary Multi-Peptide Lash and Brow Serum, and Trybello Eyelash Serum.
More information is available at https://trybello.com/blogs/news/grandelash-md-vs-the-ordinary-vs-trybello-lash-serum-cost-results-reviews
The discussion follows recent safety communications from the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), which warned consumers that some prostaglandin analogue-containing eyelash serums may cause side effects including eye irritation, eyelid pigmentation changes, fat loss around the eye, and, in some cases, irreversible darkening of the iris. The agency also noted that European regulators are reviewing the cosmetic use of several prostaglandin analogues.
Simultaneously, manufacturers like Trybello are developing prostaglandin-free formulations built around peptides, amino acids, vitamins, and botanical extracts. A 2025 survey conducted by the Danish Environmental Protection Agency found that almost 90% of the prostaglandin-free eyelash and eyebrow serums it reviewed relied on peptides and amino acids as their primary active ingredients, with no significant health concerns identified for the peptide ingredients assessed.
Trybello's new guide explores how these different formulation approaches compare in practice. Rather than focusing solely on lash growth claims, it examines ingredient composition, application methods, expected timelines for visible results, pricing, and the differing mechanisms by which prostaglandin-based and peptide-based products support lash appearance.
Among the products evaluated, GrandeLASH-MD represents the prostaglandin analogue category, while The Ordinary Multi-Peptide Lash and Brow Serum and Trybello Eyelash Serum both follow prostaglandin-free approaches. The guide explains that although prostaglandin analogues are generally associated with faster and more dramatic lash growth, peptide-based formulations instead seek to improve the appearance of lashes by supporting their strength, conditioning, and resilience while avoiding ingredients linked to a greater risk of ocular side effects.
The publication also positions ingredient transparency as an important consideration for consumers seeking to balance cosmetic performance with personal preferences regarding formulation and tolerability. For additional information, visit https://trybello.com/